Human alanyl-tRNA synthetase Protein, His Tag
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Product Number
KMP2803
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Alias
丙氨酰-tRNA合成酶, Human alanyl-tRNA synthetase Protein, His Tag, alanyl-tRNA synthetase
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 丙氨酰-tRNA合成酶, Human alanyl-tRNA synthetase Protein, His Tag, alanyl-tRNA synthetase |
| Catalog Number | KMP2803 |
| Product Description | The Human alanyl-tRNA synthetase Protein(KMP2803) is produced in Insect Cells. The target gene encoding the human AARS (NP_001596.2) (Met1-Asn968) is expressed with a polyhistidine tag at the N-terminus. |
| Molecular Name | alanyl-tRNA synthetase |
| Species | Human |
| Host | Insect Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >85% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM PB, 500mM NaCl, 20% Glycerol, pH7.0 |
| Background | Alanyl-tRNA synthetase (AARS) belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. This enzyme participates in alanine and aspartate metabolism and aminoacyl-tRNA biosynthesis. Alanyl-tRNA synthetase (AlaRS) catalyzes synthesis of Ala-tRNA (Ala) and hydrolysis of mis-acylated Ser- and Gly-tRNA (Ala) at 2 different catalytic sites. Their role is not confined to catalyze the attachment of amino acids to transfer RNAs and thereby establish the rules of genetic code by virtue of matching the nucleotide triplet of anticodon with cognate amino acid. Under apoptotic conditions in cell culture, the full-length enzyme is secreted, and the two cytokine activities can be generated by leukocyte elastase, an extracellular protease. Secretion of this tRNA synthetase may contribute to apoptosis both by arresting translation and producing needed cytokines. This protein could be an attractive target of drugs against bacterial, fungal and parasitic infections. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 109.2 kDa |
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