Human IL-22BP Protein, hFc Tag
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Product Number
KMP2737
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Alias
白细胞介素-22结合蛋白, Human IL-22BP Protein, hFc Tag, IL-22BP
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 白细胞介素-22结合蛋白, Human IL-22BP Protein, hFc Tag, IL-22BP |
| Catalog Number | KMP2737 |
| Product Description | The Human IL-22BP Protein(KMP2737) is produced in HEK293 Cells. The target gene encoding the human IL22RA2 (NP_443194.1) (Met1-Pro263) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | IL-22BP |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type II cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in the placenta, spleen, breast, skin, and lung. It is also detected in the intestinal tract, testis, brain, heart, and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of the IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important role in the immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptors have been discovered, a membrane-bound receptor and a soluble receptor. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 55 kDa |
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