Human BMP4 Protein
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Product Number
KMP2667
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Alias
骨形态发生蛋白4, Human BMP4 Protein, BMP4
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 骨形态发生蛋白4, Human BMP4 Protein, BMP4 |
| Catalog Number | KMP2667 |
| Product Description | The Human BMP4 Protein(KMP2667) is produced in E. coli. The target gene encoding the human BMP4 (P12644) (Ser293-Arg408, E399D) is expressed. |
| Molecular Name | BMP4 |
| Species | Human |
| Host | E. coli |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 30% Acetonitrile, 1/1000 TFA |
| Background | BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 13.25 kDa |
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