Human TLR3 Protein, His Tag
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Product Number
KMP2513
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Alias
Toll样受体3, Human TLR3 Protein, His Tag, TLR3
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | Toll样受体3, Human TLR3 Protein, His Tag, TLR3 |
| Catalog Number | KMP2513 |
| Product Description | The Human TLR3 Protein(KMP2513) is produced in Insect Cells. The target gene encoding the Human TLR3 (AAH59372.1) (Lys27-Ser711) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | TLR3 |
| Species | Human |
| Host | Insect Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM Tris, 300mM NaCl, 10% Glycerol, pH8.0 |
| Background | Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 is a nucleotide-sensing TLR that is activated by double-stranded RNA, a sign of viral infection. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 79.38 kDa |
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