Human VCAM1 Protein, His Tag, Avi Tag

Name: Human VCAM1 Protein, His Tag, Avi Tag
Brand: KMD Bioscience
SKU: KMP2491

Product Number

KMP2491

Alias

血管细胞粘附分子1, Human VCAM1 Protein, His Tag, Avi Tag, VCAM1

Specifications

50ug
100ug
200ug

DATASHEET MSDS

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Product Description

Alias	血管细胞粘附分子1, Human VCAM1 Protein, His Tag, Avi Tag, VCAM1
Catalog Number	KMP2491
Product Description	The Human VCAM1 Protein(KMP2491) is produced in HEK293 Cells. The target gene encoding the human VCAM1 (NP_001069.1) (Met1-Pro697) is expressed with a C-terminal polyhistidine tag followed by an Avi tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	VCAM1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	77.36 kDa

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Human VCAM1 Protein, His Tag, Avi Tag

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