Human ERBB2 Protein, His Tag
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Product Number
KMP2440
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Alias
人类表皮生长因子受体2, Human ERBB2 Protein, His Tag, ERBB2
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 人类表皮生长因子受体2, Human ERBB2 Protein, His Tag, ERBB2 |
| Catalog Number | KMP2440 |
| Product Description | The Human ERBB2 Protein(KMP2440) is produced in HEK293 Cells. The target gene encoding the human ERBB2 (AAA75493.1) (Pro489-Cys630) is expressed with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro. |
| Molecular Name | ERBB2 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >85% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 17.1 kDa |
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