Recombinant Mouse BMP4 Protein, C-His Tag

Name: Recombinant Mouse BMP4 Protein, C-His Tag
Brand: KMD Bioscience
SKU: KRP226

Product Number

KRP226

Alias

BMP-4,BMP4,BMP2B,BMP-2B,BMP2B1,Bone morphogenetic protein 4,Bone morphogenetic protein 2B,Bmp-4,Dvr-4

Specifications

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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Product Description

Alias	BMP-4,BMP4,BMP2B,BMP-2B,BMP2B1,Bone morphogenetic protein 4,Bone morphogenetic protein 2B,Bmp-4,Dvr-4
Catalog Number	KRP226
Product Introduction	Bmp4 is a secreted protein that induces the differentiation of mesenchymal stem cells into osteoblasts by activating specific signaling pathways, serving as a key inducer of bone and cartilage formation.
Expression System	HEK293F Cells
Product Description	Mouse Bmp4(293-408 aa)
Molecular Name	Bmp4
Species	Mouse
Size	20ug, 50ug, 100ug, 200ug, 1mg
Purity	≥95%
Concentration	Contact the sales manager to obtain the concentration of the latest batch.
Purification	Affinity Purification
Endotoxin	< 0.1 EU per ug
Formulation	Supplied in PBS
Background	Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (PubMed:10049358, PubMed:14973287, PubMed:15206957). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (PubMed:17301089). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus (PubMed:34995814). Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling (PubMed:27713059, PubMed:8898217). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (PubMed:29148101). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (PubMed:8898217). Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity). {ECO:0000250\|UniProtKB:P12644, ECO:0000269\|PubMed:10049358, ECO:0000269\|PubMed:14973287, ECO:0000269\|PubMed:15206957, ECO:0000269\|PubMed:17301089, ECO:0000269\|PubMed:27713059, ECO:0000269\|PubMed:29148101, ECO:0000269\|PubMed:34995814, ECO:0000269\|PubMed:8898217}.
Biological Activity	Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 forthis effect is 5- 40 ng/mL
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	12 kDa
Uniprot ID	P21275
Product Declaration	This product is for research use only and must not be used directly on the human body or for injection.

PRODUCT CENTER

Recombinant Mouse BMP4 Protein, C-His Tag

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