KRP652
CRISTIN3,RSPO1,R-spondin 1,RSPO1,R-spondin-1,Cysteine-rich and single thrombospondin domain-containing protein 3,Cristin-3,mCristin-3,Roof plate-specific spondin-1,R-spondin-1
| Alias | CRISTIN3,RSPO1,R-spondin 1,RSPO1,R-spondin-1,Cysteine-rich and single thrombospondin domain-containing protein 3,Cristin-3,mCristin-3,Roof plate-specific spondin-1,R-spondin-1 |
| Catalog Number | KRP652 |
| Product Introduction | Rspo1 is a secreted protein that specifically enhances the activity of the Wnt/ β-catenin signaling pathway, thereby promoting cell proliferation and differentiation. |
| Expression System | E. coli |
| Product Description | Mouse Rspo1(21-209aa) |
| Molecular Name | Rspo1 |
| Species | Mouse |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Purity | ≥92% |
| Concentration | Contact the sales manager to obtain the concentration of the latest batch. |
| Purification | Affinity Purification |
| Endotoxin | ＜1.0EU/ug |
| Formulation | Supplied in PBS |
| Background | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes (PubMed:21693646). Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination (By similarity). Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (By similarity). {ECO:0000250|UniProtKB:Q2MKA7, ECO:0000269|PubMed:21693646}. |
| Biological Activity | Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The typical ED50 is 50-200 ng/mL in the presence of 5 ng/mL recombinant mouse Wnt-3a. |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Molecular Weight | 28 kDa |
| Uniprot ID | Q9Z132 |
| Product Declaration | This product is for research use only and must not be used directly on the human body or for injection. |
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