Human PTN Protein
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Product Number
KMPH1426
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Alias
Pleiotropic Growth Factor, pleiotrophin, PTN, human PTN Protein, human pleiotrophin protein, HARP, HBBM, HBNF, HBGF8
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Specifications
- 20ug
- 100ug
- 1mg
Product Description
| Alias | Pleiotropic Growth Factor, pleiotrophin, PTN, human PTN Protein, human pleiotrophin protein, HARP, HBBM, HBNF, HBGF8 |
| Catalog Number | KMPH1426 |
| Molecular Name | pleiotrophin, PTN |
| Species | Human |
| Host | Baculovirus-Insect Cells |
| Size | 20ug, 100ug, 1mg |
| Purity | > 90 % as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Formulation | Lyophilized from sterile 20mM Tris, 1M NaCl, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Background | HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damage in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. |
| Application | SDS-PAGE, WB, ELISA |
| Tag | No Tag |
| Biological Activity | Measured by its binding ability in a functional ELISA. |
| Predicted N Terminus | Met |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Sequence | MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQW SVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQ AWGECDLNTALKTRTGSLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKK KKEGKKQEKMLD |
| Molecular Weight | The recombinant human PTN consists of 136 amino acids and predicts a molecular mass of 15.3 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions. |
| Uniprot ID | P21246 |
| Note | For Research Use Only! |
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