Recombinant Human Semaphorin 3A/SEMA3A Protein, His Tag
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Product Number
KMH1675
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Alias
HH16, SemD, COLL1, SEMA1, SEMAD, SEMAL, coll 1, Hsema I, SEMAIII, Hsema III, semaphorin 3A
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Specifications
- 50ug
- 100ug
Product Description
| Alias | HH16, SemD, COLL1, SEMA1, SEMAD, SEMAL, coll 1, Hsema I, SEMAIII, Hsema III, semaphorin 3A |
| Catalog Number | KMH1675 |
| Molecular Name | SEMA3A |
| Species | Human |
| Host | Mammalian cells |
| Size | 50ug, 100ug |
| Protein Family | Other protein |
| Purity | ≥90% as determined by SDS-PAGE |
| Purification | Affinity Purification |
| Endotoxin | < 1.0 EU per ug of the protein as determined by the LAL method. |
| Formulation | PBS |
| Background | Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 5 aa Sema domain. They are best characterized in relation to axon guidance during development of the nervous system. The functions of Semaphorins 3A (SEMA3A) are mediated primarily through binding to the Neuropilin-1 (Npn-1) and Plexin-A1 coreceptor complex. Neuropilins lack a signaling-competent cytoplasetmic domain and ensure semaphorin binding, whereas the transmembrane receptor plexin mediates the intracellular response. As the first identified vertebrate semaphorin, SEMA3A functions either as a chemorepulsive agent inhibiting axonal outgrowth, or as a chemoattractive agent stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Its overexpression is associated with schizophrenia which is seen in various human tumor cell lines, and aberrant release is associated with the progression of Alzheimer"s disease. |
| Storage Condition | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Molecular Weight | 82.61 kDa |
| Note | 仅供科研使用 |
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