Recombinant Human Mesothelin/MSLN Protein, Fc Tag

Name: Recombinant Human Mesothelin/MSLN Protein, Fc Tag
Brand: KMD Bioscience
SKU: KMH1393

KMH1393

MPF, SMRP, mesothelin

DATASHEET MSDS

Product Description

Alias	MPF, SMRP, mesothelin
Catalog Number	KMH1393
Molecular Name	MSLN
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	Other protein
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	Mesothelin (MSLN) was initially cloned from a library of human pancreatic cancer cells. It was also identified by a monoclonal antibody, MAb K1, which recognized a glycoprotein present on the surface of mesothelial cells. Mouse and human mesothelin are 69% identical. Mouse MSLN gene encodes a ~71 kD precursor protein of 625 amino acids. The C-terminal glycosylphosphatidylinositol (GPI) anchor addition signal is removed and replaced with a GPI anchor. The MSLN precursor is cleaved by furin into two products, a ~31 kD mature megakaryocyte potentiating factor and a ~4 kD GPI-anchored membrane-bound mature mesothelin. The 4 kD GPI-anchored mesothelin can be released by treatment with phosphatidylinositol-specific phospholipase C. Soluble mesothelin specifically binds to ovarian carcinoma cell line OVCAR-3, mediated by the cancer antigen 125 (CA125), a mucin-like glycoprotein on the surface of tumor cells.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	58.33 kDa
Note	仅供科研使用

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