Recombinant Human ACVR1 Protein, His Tag

Name: Recombinant Human ACVR1 Protein, His Tag
Brand: KMD Bioscience
SKU: KMH632

KMH632

FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2, activin A receptor type 1

DATASHEET MSDS

Product Description

Alias	FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2, activin A receptor type 1
Catalog Number	KMH632
Molecular Name	ACVR1
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	Other protein
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	ACVR1 is a receptor serine/threonine kinase that is member of the ACVR family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ACVR1, but not TGFβRI (ACVR1), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ACVR1 is sufficient to restore a low-motility phenotype in endoglin deficient cells. Therefore, endoglin decreases prostate cancer cell motility through activation of the ACVR-Smad1 pathway. ACVR1 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	11.44 kDa
Note	仅供科研使用

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