Human CD223 Protein, Fc Tag

Name: Human CD223 Protein, Fc Tag
Brand: KMD Bioscience
SKU: KMP2428

KMP2428

淋巴细胞活化基因3, Lymphocyte activation gene 3 protein, LAG3

DATASHEET MSDS

Product Description

Alias	淋巴细胞活化基因3, Lymphocyte activation gene 3 protein, LAG3
Catalog Number	KMP2428
Product Description	The Human CD233 Protein(KMP2428) is produced in HEK293 Cells and the target gene encoding Leu23-Leu450 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD223
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin(Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
SDS-PAGE
Predicted Molecular Weight	46.19 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

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