Human CD137L Protein, His Tag
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Product Number
KMP2413
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Alias
肿瘤坏死因子配体超家族成员 9, CD137L, TNFSF9
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 肿瘤坏死因子配体超家族成员 9, CD137L, TNFSF9 |
| Catalog Number | KMP2413 |
| Product Description | The Human CD137L Protein(KMP2413) is produced in E.coli and the target gene encoding Arg71-Glu254 is expressed with a 6His tag at the C-terminus. |
| Molecular Name | CD137L |
| Species | Human |
| Host | E. coli |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM TrisHCl, 150mM NaCl, pH7.4 |
| Background | Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain, placenta, lung, skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine may have a role in activation-induced cell death(AICD) and cognate interactions between T-cells and B-cells/macrophages. It has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction. |
| SDS-PAGE | |
| Predicted Molecular Weight | 20.9 kDa |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | P41273 |
| References | J. Biol. Chem. 285:9202-9210 (2010) |
| Function | Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. |
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