Human CD278 Protein, Fc Tag
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Product Number
KMP2410
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Alias
诱导性 T 细胞成本刺激器, Inducible T-cell costimulator, CD278
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 诱导性 T 细胞成本刺激器, Inducible T-cell costimulator, CD278 |
| Catalog Number | KMP2410 |
| Product Description | The Human CD278 Protein(KMP2410) is produced in HEK293 Cells and the target gene encoding Glu21-Phe141 is expressed with a Fc tag at the C-terminus. |
| Molecular Name | CD278 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige |
| SDS-PAGE | |
| Predicted Molecular Weight | 13.75 kDa |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | Q9Y6W8 |
| References | 1.Eur. J. Immunol. 30:3707-3717 (2000) 2.Nature 397:263-266 (1999) |
| Function | Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). |
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