Macaca Fascicularis CD223 Protein, His Tag

Name: Macaca Fascicularis CD223 Protein, His Tag
Brand: KMD Bioscience
SKU: KMP2389

KMP2389

淋巴细胞活化基因3, Lymphocyte activation gene 3 protein, LAG3

DATASHEET MSDS

Product Description

Alias	淋巴细胞活化基因3, Lymphocyte activation gene 3 protein, LAG3
Catalog Number	KMP2389
Product Description	The Macaca Fascicularis CD233 Protein(KMP2389) is produced in HEK293 Cells and the target gene encoding Ala18-Leu450 is expressed with a 8His tag at the N-terminus.
Molecular Name	CD223
Species	Macaca Fascicularis
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Lymphocyte Activating 3(LAG3) belongs to immunoglobulin(Ig) superfamily, Macaca fascicularis LAG3 cDNA encodes 533 amino acids(aa) that include a 17 aa signal sequence, a 451 aa extracellular domain(ECD) with two Ig-like domains, a transmembrane region and a highly charged cytoplasmic region. LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4.The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function.
Predicted Molecular Weight	48.18 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

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