Mouse CD40L Receptor Protein, His Tag
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Product Number
KMP2315
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Alias
肿瘤坏死因子受体超家族成员 5, Tumor Necrosis Factor Receptor Superfamily member 5, CD40L
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 肿瘤坏死因子受体超家族成员 5, Tumor Necrosis Factor Receptor Superfamily member 5, CD40L |
| Catalog Number | KMP2315 |
| Product Description | The Mouse CD40L Receptor Protein(KMP2315) is produced in HEK293 Cells and the target gene encoding Leu20-Arg193 is expressed with a 6His tag at the C-terminus. |
| Molecular Name | CD40 |
| Species | Mouse |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand(CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins(adaptor proteins) have been identified to serves as mediators of the signal transduction. CD40 plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. |
| SDS-PAGE | |
| Predicted Molecular Weight | 20.19 kDa |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | P27512 |
| References | EMBO J. 22:3855-3864 (2003) |
| Function | Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (PubMed:12881420). |
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