Human VSTM3 Protein, Fc Tag
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Product Number
KMP2306
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Alias
具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体, T-cell immunoreceptor with Ig and ITIM domains,, VSIG9
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体, T-cell immunoreceptor with Ig and ITIM domains,, VSIG9 |
| Catalog Number | KMP2306 |
| Product Description | The Human VSTM3 Protein(KMP2306) is produced in HEK293 Cells and the target gene encoding Met22-Pro141 is expressed with a Fc tag at the C-terminus. |
| Molecular Name | VSTM3 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | T cell immunoreceptor with Ig and ITIM domains(TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells(DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding to CD155 can antagonize the effects of DNAM1. |
| SDS-PAGE | |
| Predicted Molecular Weight | 13.06 kDa |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | A0A0C4DGA4#structure |
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