Human CD30 Protein, His Tag, Avi Tag
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Product Number
KMP2273
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Alias
肿瘤坏死因子受体8, Tumor necrosis factor receptor superfamily member 8, CD30
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 肿瘤坏死因子受体8, Tumor necrosis factor receptor superfamily member 8, CD30 |
| Catalog Number | KMP2273 |
| Product Description | The Human CD30 Protein(KMP2273) is produced in HEK293 Cells and the target gene encoding Phe19-Lys379 is expressed with a 6His, Avi tag at the C-terminus. |
| Molecular Name | CD30 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM PB, 150mM NaCl, pH7.4 |
| Background | CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L(CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma(ALCL) and classical Hodgkin lymphoma(cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate. |
| SDS-PAGE | |
| Predicted Molecular Weight | 39.25 kDa |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | P28908 |
| References | 1.Cell 73:1349-1360 (1993) 2.J. Biol. Chem. 272:2042-2045 (1997) |
| Function | Receptor for TNFSF8/CD30L . May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B . |
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