KMP2266
肿瘤坏死因子配体超家族成员 18, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor ligand superfamily member 18, TNFSF18
| Alias | 肿瘤坏死因子配体超家族成员 18, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor ligand superfamily member 18, TNFSF18 |
| Catalog Number | KMP2266 |
| Product Description | The Cynomolgus TNFSF18 Protein(KMP2266) is produced in HEK293 Cells and the target gene encoding Glu74-Ser199 is expressed with a 6His tag at the C-terminus. |
| Molecular Name | TNFSF18 |
| Species | Cynomolgus |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation. |
| SDS-PAGE | |
| Predicted Molecular Weight | 14.52 kDa |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | A0A2K5UCD9 |
Service Account
0
