Rhesus ERBB3 Protein, His Tag, Avi Tag
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Product Number
KMP4290
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Alias
受体酪氨酸蛋白激酶erbB-3, ERBB3 Protein, Rhesus ERBB3 Protein, His Tag, Avi Tag
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 受体酪氨酸蛋白激酶erbB-3, ERBB3 Protein, Rhesus ERBB3 Protein, His Tag, Avi Tag |
| Catalog Number | KMP4290 |
| Product Description | The Rhesus ERBB3 Protein(KMP4290) is produced in HEK293 Cells. A DNA sequence encoding the Rhesus ERBB3 (XP_001113953.2) (Met1-Thr643) is expressed with a C-terminal polyhistidine tag followed by an Avi tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. |
| Molecular Name | ERBB3 |
| Species | Rhesus |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 71.92 kDa |
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