Mouse CES1 Protein, His Tag
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Product Number
KMP4130
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Alias
羧酸酯酶1, CES1 Protein, Mouse CES1 Protein, His Tag
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 羧酸酯酶1, CES1 Protein, Mouse CES1 Protein, His Tag |
| Catalog Number | KMP4130 |
| Product Description | The Mouse CES1 Protein(KMP4130) is produced in HEK293 Cells. A DNA sequence encoding the Mouse CES1 (Q8VCC2) (Met1-Leu565) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | CES1 |
| Species | Mouse |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | CES1 encodes carboxylesterase-1, an important drug-metabolizing enzyme with high expression in the liver. Variants generated by the exchange of segments with CES1P1 complicate the genotyping of CES1. CES1 is involved in the hydrolysis of ester group-containing xenobiotic and endobiotic compounds including several essential and commonly used drugs. The individual variation in the efficacy and tolerability of many drugs metabolized by CES1 is considerable. However, it has been problematic to express recombinant CES1 in bacterial expression systems due to low solubility, with the CES1 protein being mainly expressed in inclusion bodies, accompanied by insufficient purity issues. CES1 is capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and endogenous compounds. Accumulating studies have demonstrated associations between the expression and activity of CES1 and the pharmacokinetics and/or pharmacodynamics of CES1 substrate medications. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 62.25 kDa |
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