Mouse PRKAR1A Protein, His Tag
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Product Number
KMP4068
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Alias
蛋白激酶cAMP依赖性I型调节亚基α, PRKAR1A Protein, Mouse PRKAR1A Protein, His Tag
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 蛋白激酶cAMP依赖性I型调节亚基α, PRKAR1A Protein, Mouse PRKAR1A Protein, His Tag |
| Catalog Number | KMP4068 |
| Product Description | The Mouse PRKAR1A Protein(KMP4068) is produced in Insect Cells. A DNA sequence encoding the Mouse PRKAR1A (NP_068680.1) (Met1-Val381) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | PRKAR1A |
| Species | Mouse |
| Host | Insect Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM Tris, 300mM NaCl, 10% Glycerol, pH7.5 |
| Background | PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating PKA, which transduces the signal throughphosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. PRKAR1A was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids Three alternatively spliced transcript variants encoding the same protein have been observed. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 44.6 kDa |
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