Mouse FDPS Protein, His Tag
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Product Number
KMP4051
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Alias
法尼基二磷酸合酶, FDPS Protein, Mouse FDPS Protein, His Tag
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 法尼基二磷酸合酶, FDPS Protein, Mouse FDPS Protein, His Tag |
| Catalog Number | KMP4051 |
| Product Description | The Mouse FDPS Protein(KMP4051) is produced in E. coli. A DNA sequence encoding the Mouse Fdps (NP_608219.1) (Met1-Lys353) is expressed with a polyhistidine tag at the N-terminus. |
| Molecular Name | FDPS |
| Species | Mouse |
| Host | E. coli |
| Size | 50ug, 100ug, 200ug |
| Purity | >85% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 50mM Tris, pH8.0 |
| Background | Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions as key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate, a precurcor for several classes of essential metabolites. FDPS catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Functions of FDPS may be inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 42.8 kDa |
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