Human Claudin-9 Protein, His Tag, Avi Tag
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Product Number
KMP3452
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Alias
紧密蛋白 9, Human Claudin-9 Protein, His Tag, Avi Tag, Claudin-9
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 紧密蛋白 9, Human Claudin-9 Protein, His Tag, Avi Tag, Claudin-9 |
| Catalog Number | KMP3452 |
| Product Description | The Human Claudin-9 Protein(KMP3452) is produced in HEK293 Cells. The target gene encoding the human CLDN9 (O95484) (Met1-Thr184) is expressed, with a polyhistidine tag followed by an Avi tag at the C-terminus. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. |
| Molecular Name | Claudin-9 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >80% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 10mM HEPES, 50mM NaCl, pH7.5 |
| Background | Claudin-9 (CLDN9) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and a cytoplasmic C tail. CLDN9 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It forms heterotypic interactions with other claudins to create cation-selective channels in the kidney and may contribute to the maintenance of alveolar barrier function in the lung. Deficiency is shown to be associated with autosomal recessive deafness, DFNB116. CLDN9 expression has been shown to be upregulated in certain types of cancer, such as endometrial cancer and hepatocellular carcinoma, and its knockdown has been found to reduce cell proliferation and migration in vitro. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 22.44 kDa |
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