Human HK2 Protein, His Tag
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Product Number
KMP3428
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Alias
己糖激酶 2, Human HK2 Protein, His Tag, HK2
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 己糖激酶 2, Human HK2 Protein, His Tag, HK2 |
| Catalog Number | KMP3428 |
| Product Description | The Human HK2 Protein(KMP3428) is produced in Insect Cells. The target gene encoding the Human HK2 (P52789) (Met1-Arg917) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | HK2 |
| Species | Human |
| Host | Insect Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM PB, 300mM NaCl, 10% Glycerol, pH7.0 |
| Background | Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of the glycolysis pathway, expresses at a high level in cancer cells compared with normal cells. HK2 provides a new target for cancer therapy due to its pivotal role in tumor tumourigenic and metastatic processes. The glycolytic enzyme hexokinase 2 (HK2) is crucial for the Warburg effect in human glioma, the most common malignant brain tumor. Although absent in most adult tissues, hexokinase 2 (HK2) is expressed in a majority of tumors and contributes to increased glucose consumption and to in vivo tumor 18F-FDG PET signaling. Hexokinase 2 (HK2) is a rate-determining enzyme in aerobic glycolysis, a process upregulated in tumor cells. HK2 expression is controlled by various transcription factors and epigenetic alterations and is heterogeneous in hepatocellular carcinomas (HCCs), though the cause of this heterogeneity is not known. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 103.84 kDa |
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