Human Gastrokine 1 Protein, His Tag
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Product Number
KMP3353
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Alias
胃泌素 1, Human Gastrokine 1 Protein, His Tag, Gastrokine 1
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 胃泌素 1, Human Gastrokine 1 Protein, His Tag, Gastrokine 1 |
| Catalog Number | KMP3353 |
| Product Description | The Human Gastrokine 1 Protein(KMP3353) is produced in Insect Cells. The target gene encoding the human GKN1 (Q9NS71) (Asn35-Asn199) is expressed with a C-terminal polyhistidine tag. |
| Molecular Name | Gastrokine 1 |
| Species | Human |
| Host | Insect Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM Tris, 500mM NaCl, 10% Glycerol, pH8.0 |
| Background | Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in gastric cancer. GKN1-mediated inhibition of APP processing might represent a new approach for the prevention and therapy of Alzheimer's disease (AD). In the presence of GKN2, GKN1 loses its ability to decrease cell proliferation, induce apoptosis, and inhibit epigenetic alterations in gastric cancer cells, that GKN2 may contribute to the homeostasis of gastric epithelial cells by inhibiting GKN1 activity. The loss of GKN1 function contributes to malignant transformation and proliferation of gastric epithelial cells in gastric carcinogenesis. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 19.6 kDa |
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