Human KREMEN1 Protein, His Tag
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Product Number
KMP3350
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Alias
Kringle 跨膜蛋白 1, Human KREMEN1 Protein, His Tag, KREMEN1
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | Kringle 跨膜蛋白 1, Human KREMEN1 Protein, His Tag, KREMEN1 |
| Catalog Number | KMP3350 |
| Product Description | The Human KREMEN1 Protein(KMP3350) is produced in HEK293 Cells. The target gene encoding the human KREMEN1 (NP_114434.3) (Met1-Thr394) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | KREMEN1 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection. KREMEN1 is also essential for infection by a phylogenetic and pathogenic related group of Human type A Enteroviruses (EV-As). Diseases associated with KREMEN1 include Ectodermal Dysplasia 13, Hair/Tooth Type, and Hand, Foot, And Mouth Disease. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 42.6 kDa |
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