Human MPZL3 Protein, His Tag
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Product Number
KMP3290
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Alias
髓磷脂蛋白零样 3, Human MPZL3 Protein, His Tag, MPZL3
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 髓磷脂蛋白零样 3, Human MPZL3 Protein, His Tag, MPZL3 |
| Catalog Number | KMP3290 |
| Product Description | The Human MPZL3 Protein(KMP3290) is produced in HEK293 Cells. The target gene encoding the human MPZL3 (NP_938016.1) (Met1-Ser158) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | MPZL3 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | MPZL3 (Myelin Protein Zero Like 3) is a Protein Coding gene. The encoded protein belongs to the myelin P0 protein family. MPZL3 is broadly expressed in skin, esophagus, and other tissues. MPZL3 was essential for normal differentiation, acting downstream of p63, ZNF750, KLF4, and RCOR1, each of which bound near the MPZL3 gene and controlled its expression. MPZL3 protein localized to mitochondria, where it interacted with FDXR, which was itself also found to be essential for differentiation. Together, MPZL3 and FDXR increased reactive oxygen species (ROS) to drive epidermal differentiation. ROS-induced differentiation is dependent upon the promotion of FDXR enzymatic activity by MPZL3. ROS induction by the MPZL3 and FDXR mitochondrial proteins is therefore essential for epidermal differentiation. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 15.6 kDa |
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