Human PRAP1 Protein, His Tag

Name: Human PRAP1 Protein, His Tag
Brand: KMD Bioscience
SKU: KMP3229

KMP3229

聚 (ADP-核糖) 聚合酶 1, Human PRAP1 Protein, His Tag, PRAP1

DATASHEET MSDS

Product Description

Alias	聚 (ADP-核糖) 聚合酶 1, Human PRAP1 Protein, His Tag, PRAP1
Catalog Number	KMP3229
Product Description	The Human PRAP1 Protein(KMP3229) is produced in HEK293 Cells. The target gene encoding the human PRAP1 (AAL16670.1) (Met1-Gln151) is expressed with a C-terminal polyhistidine tag.
Molecular Name	PRAP1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 may promote resistance of cancer cells to chemotherapeutic drugs such as 5-fluorouracil (5-FU), as knockdown of PRAP1 increases apoptosis in cancer cells after 5-FU treatment. PRAP1 appears to protect cells from apoptosis by inducing cell-cycle arrest, suggesting that the induction of PRAP1 expression by p53 in response to DNA-damaging agents contributes to cancer cell survival.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	16.4 kDa

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