Human BCCIP Protein
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Product Number
KMP3147
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Alias
BRCA2 和 CDKN1A 相互作用蛋白, Human BCCIP Protein, BCCIP
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | BRCA2 和 CDKN1A 相互作用蛋白, Human BCCIP Protein, BCCIP |
| Catalog Number | KMP3147 |
| Product Description | The Human BCCIP Protein(KMP3147) is produced in Insect Cells. The target gene encoding the human BCCIP (AAH09771.1) (Met1-Val314) is expressed with two additional amino acids (Gly & Pro) at the N-terminus. |
| Molecular Name | BCCIP |
| Species | Human |
| Host | Insect Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >85% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM Tris, 500mM NaCl, 3mM DTT, 10% Glycerol, pH7.4 |
| Background | BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations may overcome the progression suppression imposed by BCCIP deficiency through a synthetic viability mechanism. Knockdown of YY1 inhibited the binding of BCCIP itself at BCCIP promoter region proximal to TSS, demonstrating that transcriptional regulation of the YY1 on BCCIP can be modulated by BCCIP itself in a YY1-dependent fashion. BCCIP (BRCA2 and CDKN1A interacting protein) plays a critical role in maintaining the critical functions of p53 in tumor suppression and response to therapy. Celecoxib affects the functions of p53 and inhibits the recovery from the irradiation-induced injury by up-regulating the expression of BCCIP, and subsequently regulates the expressions of genes such as p21 and Cyclin B1 to enhance the radiosensitivity of HCT116 cells in a COX-2 independent manner. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 36.2 kDa |
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