Human ENSA Protein, His Tag
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Product Number
KMP3144
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Alias
内硫素α, Human ENSA Protein, His Tag, ENSA
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 内硫素α, Human ENSA Protein, His Tag, ENSA |
| Catalog Number | KMP3144 |
| Product Description | The Human ENSA Protein(KMP3144) is produced in E. coli. The target gene encoding the mature form of human ENSA (O43768-1) (Met1-Glu121) is expressed with a polyHistide tag at the N-terminus. The purified protein is biotinylated in vitro. |
| Molecular Name | ENSA |
| Species | Human |
| Host | E. coli |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. As a protein phosphatase inhibitor, ENSA specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase By similarity. Endosulfine alpha also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 15.2 kDa |
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