Human NPC2 Protein, His Tag
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Product Number
KMP3058
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Alias
细胞内胆固醇转运蛋白 2, Human NPC2 Protein, His Tag, NPC2
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 细胞内胆固醇转运蛋白 2, Human NPC2 Protein, His Tag, NPC2 |
| Catalog Number | KMP3058 |
| Product Description | The Human NPC2 Protein(KMP3058) is produced in HEK293 Cells. The target gene encoding the human NPC2 (NP_006423.1) (Met1-Leu151) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | NPC2 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 16 kDa |
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