Human Thrombomodulin Protein, His Tag
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Product Number
KMP2943
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Alias
血栓调节蛋白, Human Thrombomodulin Protein, His Tag, Thrombomodulin
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 血栓调节蛋白, Human Thrombomodulin Protein, His Tag, Thrombomodulin |
| Catalog Number | KMP2943 |
| Product Description | The Human Thrombomodulin Protein(KMP2943) is produced in HEK293 Cells. The target gene encoding the human THBD (NP_000352.1) (Met1-Ser515) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | Thrombomodulin |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin also regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 53.54 kDa |
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