Rabbit Anti-Human ABCB11 pAb
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Product Number
PA8315
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Alias
ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP
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Specifications
- 50ul
- 100ul
Product Description
| Alias | ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP |
| Catalog Number | PA8315 |
| Molecular Name | ABCB11 |
| Host | Rabbit |
| Size | 50ul, 100ul |
| Clonity | Polyclonal |
| Purification | Affinity Purification |
| Formulation | Supply in PBS with 0.02% sodium azide, 50% glycerol, pH 7.4. |
| Immunogen | A synthetic peptide corresponding to a sequence within a.a. 1050-1150 of human ABCB11 (NP_003733.2). |
| Application | WB, IF |
| Storage Condition | Store the product under sterile conditions after opening at -20℃. Avoid freeze-thaw cycles. |
| Shipping Condition | Shipped on ice packs. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human ABCB11 Polyclonal Antibody |
FAQ
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Q1- ABCB11（BSEP）的生理功能是什么？
ABCB11是胆汁酸转运蛋白，特异性表达于肝细胞胆小管膜，突变导致进行性家族性肝内胆汁淤积症（PFIC2）。
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Q2- 是否适用于原代肝细胞的免疫荧光染色？
是的，需冷甲醇固定（-20℃，10分钟）以保留膜定位信号。
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Q3- 抗体是否识别大鼠或小鼠的ABCB11同源蛋白？
与大鼠Abcb11同源性约85%，可检测；小鼠需验证（推荐1:500稀释）。
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Q4- 如何分析胆汁淤积模型中的蛋白表达？
结合胆管结扎（BDL）模型，通过WB定量肝组织裂解液中的ABCB11表达。
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Q5- 是否提供患者肝活检样本的验证数据？
是的，提供PFIC2患者与健康对照的IHC染色对比结果。
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Service Account
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