Rabbit Anti-Human BIRC2 pAb
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Product Number
PA4537
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Alias
API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1, BIRC2
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Specifications
- 50ul
- 100ul
Product Description
| Alias | API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1, BIRC2 |
| Catalog Number | PA4537 |
| Molecular Name | BIRC2 |
| Host | Rabbit |
| Size | 50ul, 100ul |
| Clonity | Polyclonal |
| Purification | Affinity Purification |
| Formulation | Supply in PBS with 0.02% sodium azide, 50% glycerol, pH 7.4. |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to a.a. 1-300 of human cIAP1 (NP_001157.1). |
| Application | WB, IF |
| Storage Condition | Store the product under sterile conditions after opening at -20℃. Avoid freeze-thaw cycles. |
| Shipping Condition | Shipped on ice packs. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human BIRC2 Polyclonal Antibody |
FAQ
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Q1-BIRC2的生物学功能是什么？
BIRC2（凋亡抑制蛋白c-IAP1）通过抑制Caspase活性及激活NF-κB信号促进细胞存活，其异常表达与淋巴瘤、乳腺癌等癌症的化疗耐药相关。
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Q2-是否适用于肿瘤耐药研究？
可以，推荐使用顺铂耐药的癌细胞系，通过WB检测BIRC2与TRAF2的互作及NF-κB靶基因（如BCL2）表达上调。
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Q3-是否与XIAP或BIRC3交叉反应？
经测试无交叉反应，特异性针对BIRC2。
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