BRCA1的生物学意义是什么？

BRCA1是DNA同源重组修复关键蛋白，其胚系突变显著增加乳腺癌、卵巢癌及前列腺癌风险，并影响PARP抑制剂疗效。

是否适用于遗传性癌症模型？

可以，推荐使用BRCA1突变患者来源的类器官或PDX模型，通过彗星实验检测DNA损伤累积。

经测试无交叉反应，特异性针对BRCA1。

PA4280

BRCA1, BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53

DATASHEET MSDS

Product Description

Alias	BRCA1, BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53
Catalog Number	PA4280
Molecular Name	BRCA1
Host	Rabbit
Size	50ul, 100ul
Clonity	Polyclonal
Purification	Affinity Purification
Formulation	Supply in PBS with 0.02% sodium azide, 50% glycerol, pH 7.4.
Immunogen	A synthetic peptide corresponding to a sequence within a.a. 120-220 of human BRCA1 (NP_009225.1).
Application	WB, IHC, IF
Storage Condition	Store the product under sterile conditions after opening at -20℃. Avoid freeze-thaw cycles.
Shipping Condition	Shipped on ice packs.
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。
Product Full Name	Rabbit Anti-Human BRCA1 Polyclonal Antibody

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