Rabbit Anti-Human SMAD4 Polyclonal Antibody
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Product Number
PA11508
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Alias
DPC4, JIP, MADH4, MYHRS, Smad4, SMAD4
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Specifications
- 50ul
- 100ul
Product Description
| Alias | DPC4, JIP, MADH4, MYHRS, Smad4, SMAD4 |
| Catalog Number | PA11508 |
| Molecular Name | SMAD4 |
| Host | Rabbit |
| Size | 50ul, 100ul |
| Clonity | Polyclonal |
| Purification | Affinity Purification |
| Formulation | Supply in PBS with 0.02% sodium azide, 50% glycerol, pH 7.4. |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to a.a. 160-450 of human Smad4 (NP_005350.1). |
| Application | WB, IF |
| Storage Condition | Store the product under sterile conditions after opening at -20℃. Avoid freeze-thaw cycles. |
| Shipping Condition | Shipped on ice packs. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
FAQ
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Q1-SMAD4的生物学功能是什么？
SMAD4是TGF-β/BMP信号通路的共同介质（Co-SMAD），介导信号转导与核内转录调控，其突变导致胰腺癌、结直肠癌及遗传性出血性毛细血管扩张症（HHT）。
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Q2-是否适用于癌症转移研究？
可以，推荐使用胰腺癌细胞模型，检测SMAD4缺失后的EMT标志物（如Vimentin）上调。
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Q3-是否与SMAD3交叉反应？
经测试无交叉反应，特异性针对SMAD4。
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