CACNA1A的生物学相关性是什么？

CACNA1A（电压门控钙通道α1A亚基）调控小脑神经元钙内流，其突变导致家族性偏瘫性偏头痛、脊髓小脑共济失调及癫痫。

是否适用于共济失调模型？

可以，推荐使用转基因小鼠模型，通过行为学（旋转棒实验）检测运动协调缺陷。

经测试无交叉反应，特异性针对CACNA1A。

PAV631

calcium voltage-gated channel subunit alpha1 A, APCA, BI, CACNL1A4, CAV2.1, EA2, EIEE42, FHM, HPCA, MHP, MHP1, SCA6

DATASHEET MSDS

Product Description

Alias	calcium voltage-gated channel subunit alpha1 A, APCA, BI, CACNL1A4, CAV2.1, EA2, EIEE42, FHM, HPCA, MHP, MHP1, SCA6
Catalog Number	PAV631
Molecular Name	CACNA1A
Host	Rabbit
Size	100ul
Clonity	Polyclonal
Concentration	1 mg/ml
Purification	affinity-chromatography
Formulation	supply in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen	This antibody was raised against from human CACNA1A protein at amino acid: 1401-1450
Recommended Dilution	IHC-p 1:50-300
Storage Condition	Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Shipping Condition	This product is shipped on blue ice.
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。

FAQ

Q1-CACNA1A的生物学相关性是什么？

CACNA1A（电压门控钙通道α1A亚基）调控小脑神经元钙内流，其突变导致家族性偏瘫性偏头痛、脊髓小脑共济失调及癫痫。
Q2-是否适用于共济失调模型？

可以，推荐使用转基因小鼠模型，通过行为学（旋转棒实验）检测运动协调缺陷。
Q3-是否与CACNA1B交叉反应？

经测试无交叉反应，特异性针对CACNA1A。