KMD Bioscience has been dedicated to Antibody Preparation Research for many years. Our core R&D team possesses extensive experience in custom antibody and recombinant protein production. We offer comprehensive Preparation Services for both monoclonal and polyclonal antibodies derived from camelids, including alpacas. With years of specialization in the antibody field, KMD Bioscience has established a mature and robust Antibody Preparation Platform supported by proficient experimental techniques. We prepare antibodies from diverse species such as alpacas, rabbits, goats, sheep, and humans. Leveraging our integrated platforms for antibodies, proteins, and more, we provide one-stop services encompassing antigen preparation, alpaca immunization, antibody library construction and screening, antibody expression and purification, and antibody humanization. Additionally, our experienced technical team will develop detailed experimental protocols and customized quotations tailored to your project, delivering antibody preparation services that save clients valuable research funding and time.

Human immunoglobulin IgG consists of two heavy chains and two light chains, whereas camelid antibodies possess only heavy chains. These naturally light-chain-deficient antibodies are termed Heavy Chain Antibodies (hcAbs). The antigen-binding domain of camelid antibodies contains three Complementarity-Determining Regions (CDRs). Compared to conventional antibodies, camelid antibodies exhibit excellent antigen recognition and binding capabilities even without a light chain. Due to the absence of the light chain, the antigen-binding fragment of camelid antibodies, known as the VHH domain, has a molecular weight of only 12-15 kDa, significantly smaller than the antigen-binding fragment of conventional antibodies. Compared to traditional antibodies, alpaca antibodies demonstrate high stability, maintaining activity at 60°C and resisting a broad pH range. Consequently, these antibodies offer numerous advantages: small molecular size, high stability, ease of genetic engineering, low immunogenicity, strong specificity, high affinity, and high expression yields in both eukaryotic and prokaryotic systems. Due to their high amino acid sequence similarity to human antibody heavy chains, they are more amenable to humanization and are widely applied in current therapeutic antibody research.

KMD Bioscience provides customized alpaca polyclonal antibodies in various specifications. Simultaneously, based on phage display technology, KMD also offers the construction of alpaca antibody phage display libraries and the screening of desired monoclonal antibodies for clients. We possess a one-stop Therapeutic Antibody Screening Platform, complemented by antibody engineering services such as humanization and affinity maturation. This enables us to provide clients with comprehensive antibody research, development, and production services.